“Super” SERPINs—A stabilizing force against fibrinolysis in thromboinflammatory conditions

The superfamily of serine protease inhibitors (SERPINs) are a class of inhibitors that utilise a dynamic conformational change to trap and inhibit their target enzymes. Their powerful nature lends itself well to regulation of complex physiological enzymatic cascades, such as the haemostatic, inflamm...

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Bibliographic Details

Published in:	Frontiers in Cardiovascular Medicine
Main Authors:	Steven J. Humphreys, Claire S. Whyte, Nicola J. Mutch
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-04-01
Subjects:	SERPIN thromboinflammation plasminogen activator-inhibitor-1 α2-antiplasmin protease nexin-1 C1-inhibitor
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2023.1146833/full