A novel intervertebral disc bioreactor system for studying clinically based active dynamic unloading combining biological and biomechanical outcomes

Background: Intervertebral disc (IVD) degeneration relies on a complex interrelated cascade of biological and mechanical processes in which loss of water content plays an important role. Despite the positive effects of unloading on clinical outcome parameters and IVD hydration, the biological and me...

Full description

Bibliographic Details

Published in:	European Cells & Materials
Main Authors:	A Soubrier, H Kasper, G Miklosic, M Alini, I Jonkers, S Grad
Format:	Article
Language:	English
Published:	Forum Multimedia Publishing LLC 2025-04-01
Subjects:	intervertebral disc mechanobiology traction unloading bioreactor bovine organ model
Online Access:	https://www.ecmjournal.org/papers/vol050/vol050a01.php