Multi-omics reveals the alleviating effect of berberine on ulcerative colitis through modulating the gut microbiome and bile acid metabolism in the gut-liver axis

The dysfunction of gut microbiome and bile acid metabolism might cause the incidence and relapse of ulcerative colitis (UC). Thus, natural products have been considered effective for UC through the regulation of gut microbiome and bile acid. In this study, we evaluated the regulatory effect of berbe...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Jingsheng Yu, Yixuan Zheng, Changmin Liu, Zhuangyuan Xie, Qingqing Liu, Shuai Yang, Qianqian Tian, Chi Song, Shilin Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-10-01
Subjects:	ulcerative colitis berberine gut microbiome bile acid s1pr2 intestinal barrier
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1494210/full