Neuroimaging of tissue microstructure as a marker of neurodegeneration in the AT(N) framework: defining abnormal neurodegeneration and improving prediction of clinical status

Abstract Background Alzheimer’s disease involves accumulating amyloid (A) and tau (T) pathology, and progressive neurodegeneration (N), leading to the development of the AD clinical syndrome. While several markers of N have been proposed, efforts to define normal vs. abnormal neurodegeneration based...

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Bibliographic Details

Published in:	Alzheimer’s Research & Therapy
Main Authors:	Rigina L. Gallagher, Rebecca Langhough Koscik, Jason F. Moody, Nicholas M. Vogt, Nagesh Adluru, Steven R. Kecskemeti, Carol A. Van Hulle, Nathaniel A. Chin, Sanjay Asthana, Gwendlyn Kollmorgen, Ivonne Suridjan, Cynthia M. Carlsson, Sterling C. Johnson, Douglas C. Dean, Henrik Zetterberg, Kaj Blennow, Andrew L. Alexander, Barbara B. Bendlin
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Subjects:	Neuroimaging Diffusion-weighted imaging CSF biomarkers Alzheimer’s disease Neurodegeneration
Online Access:	https://doi.org/10.1186/s13195-023-01281-y