Edoxaban pharmacokinetics during in vitro continuous renal replacement therapy

Abstract Background To evaluate the clearance of edoxaban during modeled in vitro continuous renal replacement therapy (CRRT), assess protein binding and circuit adsorption, and provide initial dosing recommendations. Methods Edoxaban was added to the CRRT circuit and serial pre-filter bovine blood...

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Bibliographic Details

Published in:	BMC Nephrology
Main Authors:	Eric Wenzler, Kaitlyn Dalton, Lauren Andrews, Scott T. Benken
Format:	Article
Language:	English
Published:	BMC 2024-10-01
Subjects:	Edoxaban Pharmacokinetics Dialysis Renal replacement therapy Sieving coefficient Saturation coefficient
Online Access:	https://doi.org/10.1186/s12882-024-03777-7