PD-1 blockade combined with IL-33 enhances the antitumor immune response in a type-1 lymphocyte-mediated manner

PD-1 immune checkpoint blockade and cytokine IL-33 have shown significant therapeutic effects in tumor immunotherapy. These therapies promote CD8+ T cell activation, proliferation, and effector functions. However, there were few research about the combined therapy efficacy. In this study, we establi...

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Bibliographic Details

Published in:	Cancer Treatment and Research Communications
Main Authors:	Honghong He, Liyan Shi, Dan Meng, Huijun Zhou, Jingshu Ma, Yixian Wu, Yanshi Wu, Yanzheng Gu, Wei Xie, Jing Zhang, Yibei Zhu
Format:	Article
Language:	English
Published:	Elsevier 2021-01-01
Subjects:	Immune checkpoint blockade PD-1 IL-33 Melanoma Tumor immunotherapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S2468294221000770