M402, a novel heparan sulfate mimetic, targets multiple pathways implicated in tumor progression and metastasis.

Heparan sulfate proteoglycans (HSPGs) play a key role in shaping the tumor microenvironment by presenting growth factors, cytokines, and other soluble factors that are critical for host cell recruitment and activation, as well as promoting tumor progression, metastasis, and survival. M402 is a ratio...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	He Zhou, Sucharita Roy, Edward Cochran, Radouane Zouaoui, Chia Lin Chu, Jay Duffner, Ganlin Zhao, Sean Smith, Zoya Galcheva-Gargova, Juliane Karlgren, Nancy Dussault, Rain Y Q Kwan, Erick Moy, Marishka Barnes, Alison Long, Chris Honan, Yi Wei Qi, Zachary Shriver, Tanmoy Ganguly, Birgit Schultes, Ganesh Venkataraman, Takashi Kei Kishimoto
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2011-01-01
Online Access:	http://europepmc.org/articles/PMC3116871?pdf=render