Refinement of the pilocarpine-induced status epilepticus model in mice to improve mortality outcomes

Systemic pilocarpine administration has been widely implemented to generate rodent models of mesial temporal lobe epilepsy (mTLE), but pilocarpine-induced status epilepticus (SE) in mice causes a high mortality rate, likely due to cardiorespiratory collapse associated with prolonged seizures. Althou...

Full description

Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Authors:	Mi Jiang, Yu Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Subjects:	levetiracetam pilocarpine status epilepticus mortality rate mesial temporal lobe epilepsy
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2025.1592014/full