rAAV expressing recombinant neutralizing antibody for the botulinum neurotoxin type A prophylaxis

Botulinum neurotoxin (BoNT) is one of the most dangerous bacterial toxins and a potential biological weapon component. BoNT mechanism of pathological action is based on inhibiting the release of neurotransmitters from nerve endings. To date, anti-BoNT therapy is reduced to the use of horse hyperimmu...

Full description

Bibliographic Details

Published in:	Frontiers in Microbiology
Main Authors:	Artem A. Derkaev, Ekaterina I. Ryabova, Ilias B. Esmagambetov, Dmitry V. Shcheblyakov, Svetlana A. Godakova, Irina D. Vinogradova, Anatoly N. Noskov, Denis Y. Logunov, Boris S. Naroditsky, Alexander L. Gintsburg
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-09-01
Subjects:	adeno-associated viral vector (AAV) single-domain antibodies VHH botulinum neurotoxin Clostridium botulinum botulism
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2022.960937/full