Optimization of the Factors Affecting the Absorption of Vardenafil from Oral Disintegrating Tablets: A Clinical Pharmacokinetic Investigation

Because of poor solubility and considerable metabolism, vardenafil (VRD) bioavailability is 15%. To overcome this obstacle, this study aimed to increase the solubility, hasten the onset of action, and mask the unpleasant taste of VRD utilizing β-cyclodextrin (β-CD) and formulation...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Hytham A. Al-Gethmy, Usama A. Fahmy, Nabil A. Alhakamy, Osama A. A. Ahmed, Khalid M. El-Say
Format:	Article
Language:	English
Published:	MDPI AG 2019-01-01
Subjects:	bioavailability Box–Behnken design β-cyclodextrin erectile dysfunction taste masking vardenafil
Online Access:	http://www.mdpi.com/1999-4923/11/1/11