Substrate Stiffness Modulates TGF-β Activation and ECM-Associated Gene Expression in Fibroblasts

Transforming growth factor-β (TGF-β) is a multifunctional cytokine that regulates the expression of ECM-associated genes during early injury. Tissue fibrosis development is driven by synergistic cues between the evolving biochemical and mechanical milieu. Few studies have addressed the role of subst...

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Bibliographic Details

Published in:	Bioengineering
Main Authors:	Brijesh Kumar Verma, Aritra Chatterjee, Paturu Kondaiah, Namrata Gundiah
Format:	Article
Language:	English
Published:	MDPI AG 2023-08-01
Subjects:	polydimethylsiloxane cell–matrix interactions collagen MMP TGF-β, substrate stiffness
Online Access:	https://www.mdpi.com/2306-5354/10/9/998