High-throughput screening and characterization of novel inhibitors targeting HIV-1 protease precursor autoprocessing

Abstract HIV-1 protease (PR) is initially synthesized as part of the Gag-Pol polyprotein precursor, which undergoes temporospatially regulated autoprocessing to liberate mature PR. The free mature enzyme is the target of currently available protease inhibitors (PIs). To explore alternative therapeut...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Ryan H. Jeep, Liangqun Huang, Tram A. Ngo, Fu-Yue Zeng, James Boehlke, Luke Bennett, Stanton Ashman, Ian Pass, Thomas D. Y. Chung, Chaoping Chen
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-10-01
Online Access:	https://doi.org/10.1038/s41598-025-19090-8