Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids

Abstract In this research, a 3D brain organoid model is developed to study POLG‐related encephalopathy, a mitochondrial disease stemming from POLG mutations. Induced pluripotent stem cells (iPSCs) derived from patients with these mutations is utilized to generate cortical organoids, which exhibited...

Full description

Bibliographic Details

Published in:	Advanced Science
Main Authors:	Anbin Chen, Tsering Yangzom, Yu Hong, Bjørn Christian Lundberg, Gareth John Sullivan, Charalampos Tzoulis, Laurence A. Bindoff, Kristina Xiao Liang
Format:	Article
Language:	English
Published:	Wiley 2024-05-01
Subjects:	cortical organoids iPSC mitochondrial function neuron POLG
Online Access:	https://doi.org/10.1002/advs.202307136