Hallmark Molecular and Pathological Features of POLG Disease are Recapitulated in Cerebral Organoids

Abstract In this research, a 3D brain organoid model is developed to study POLG‐related encephalopathy, a mitochondrial disease stemming from POLG mutations. Induced pluripotent stem cells (iPSCs) derived from patients with these mutations is utilized to generate cortical organoids, which exhibited...

書目詳細資料
發表在:	Advanced Science
Main Authors:	Anbin Chen, Tsering Yangzom, Yu Hong, Bjørn Christian Lundberg, Gareth John Sullivan, Charalampos Tzoulis, Laurence A. Bindoff, Kristina Xiao Liang
格式:	Article
語言:	英语
出版:	Wiley 2024-05-01
主題:	cortical organoids iPSC mitochondrial function neuron POLG
在線閱讀:	https://doi.org/10.1002/advs.202307136

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