Trypanosoma cruzi: inhibition of alpha-hydroxyacid dehydrogenase isozyme II by N-allyl and N-propyl oxamates and their effects on intact epimastigotes

N-allyl (NAOx) and N-propyl (NPOx) oxamates were designed as inhibitors of alpha-hydroxyacid dehydrogenase (HADH) isozyme II from Trypanosoma cruzi. The kinetic studies showed that NAOx and NPOx were competitive inhibitors of HADH-isozyme II (Ki = 72 µM, IC50 = 0.33 mM and 70 µM, IC50 = 0.32 mM, res...

詳細記述

書誌詳細

出版年:	Memorias do Instituto Oswaldo Cruz
主要な著者:	Miguel A Chena, Silvia Elizondo-Jiménez, Lorena Rodríguez-Páez, Benjamín Nogueda-Torres, Isabel Baeza-Ramírez, Carlos Wong-Ramírez
フォーマット:	論文
言語:	英語
出版事項:	Fundação Oswaldo Cruz (FIOCRUZ) 2004-12-01
主題:	Trypanosoma cruzi Trypanosoma cruzi alpha-hydroxyacid dehydrogenase-isozyme II inhibition N-allyl oxamate N-propyl oxamate ethyl N-propyl oxamate ethyl N-allyl oxamate alpha-hydroxyacid dehydrogenase
オンライン･アクセス:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000800009