High prevalence of NTRK fusions in sporadic dMMR/MSI mCRC RAS/RAF wild-type: an opportunity for a post-immune checkpoint inhibitors progression rescue strategy

Background: Currently, mismatch repair deficient/microsatellite instable (dMMR/MSI) status constitutes a validated predictive marker of response to immune checkpoint inhibitors (ICIs) in patients with metastatic colorectal cancer (mCRC). Unfortunately, some of these patients do not benefit from ICIs...

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发表在:	ESMO Gastrointestinal Oncology
Main Authors:	M. Svrcek, A. Cayre, T. Samaille, R. Colle, L. Mas, P. Bourgoin, E. Guillerm, R. Cohen, F. Penault-Llorca, T. André, N. Radosevic-Robin
格式:	文件
语言:	英语
出版:	Elsevier 2024-09-01
主题:	tropomyosin receptor kinase mismatch repair deficient metastatic colorectal cancer immune checkpoint inhibitors
在线阅读:	http://www.sciencedirect.com/science/article/pii/S2949819824000451