Targeting Hypoxia-Inducible Factor-1 (HIF-1) in Cancer: Emerging Therapeutic Strategies and Pathway Regulation

Hypoxia-inducible factor-1 (HIF-1) is a key regulator for balancing oxygen in the cells. It is a transcription factor that regulates the expression of target genes involved in oxygen homeostasis in response to hypoxia. Recently, research has demonstrated the multiple roles of HIF-1 in the pathophysi...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Reem A. Qannita, Ayah I. Alalami, Amani A. Harb, Shereen M. Aleidi, Jalal Taneera, Eman Abu-Gharbieh, Waseem El-Huneidi, Mohamed A. Saleh, Karem H. Alzoubi, Mohammad H. Semreen, Mohammad Hudaib, Yasser Bustanji
Format:	Article
Language:	English
Published:	MDPI AG 2024-02-01
Subjects:	hypoxia-inducible factor-1 hypoxia cancer HIF-1α metabolism reprogramming HIF-1 inhibitors
Online Access:	https://www.mdpi.com/1424-8247/17/2/195