Fabrication and evaluation of smart pH/thermo dual-responsive injectable intratumoral in situ depot hydrogels for controlled 5-FU delivery

Abstract Background 5-FU has multiple applications in various cancers but has limitations owing to its shorter half-life and rapid metabolism. In this study, injectable intratumoral gels were developed to enhance 5-FU concentrations in tumor vicinity. Sterile tunable poly (N-isopropylacrylamide)-bas...

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Bibliographic Details

Published in:	Beni-Suef University Journal of Basic and Applied Sciences
Main Authors:	Samiullah Khan, Bangul Khan, Huan Li
Format:	Article
Language:	English
Published:	SpringerOpen 2023-12-01
Subjects:	Dual-responsive gels Intratumor depot 5-Fluorouracil MCF-7 cancer cells Low viscous chitosan Vero cell lines
Online Access:	https://doi.org/10.1186/s43088-023-00459-5