From Personalized to Precision Medicine in Oncology: A Model-Based Dosing Approach to Optimize Achievement of Imatinib Target Exposure

Imatinib is a targeted cancer therapy that has significantly improved the care of patients with chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST). However, it has been shown that the recommended dosages of imatinib are associated with trough plasma concentration (Cmin) lower t...

Full description

Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Sylvain Goutelle, Monia Guidi, Verena Gotta, Chantal Csajka, Thierry Buclin, Nicolas Widmer
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Subjects:	imatinib pharmacokinetics model-informed precision dosing oncology antineoplasic agents
Online Access:	https://www.mdpi.com/1999-4923/15/4/1081