Synthetic circuits reveal how mechanisms of gene regulatory networks constrain evolution

Abstract Phenotypic variation is the raw material of adaptive Darwinian evolution. The phenotypic variation found in organismal development is biased towards certain phenotypes, but the molecular mechanisms behind such biases are still poorly understood. Gene regulatory networks have been proposed a...

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Bibliographic Details

Published in:	Molecular Systems Biology
Main Authors:	Yolanda Schaerli, Alba Jiménez, José M Duarte, Ljiljana Mihajlovic, Julien Renggli, Mark Isalan, James Sharpe, Andreas Wagner
Format:	Article
Language:	English
Published:	Springer Nature 2018-09-01
Subjects:	constrained evolution epistasis gene regulatory networks regulatory mechanisms synthetic circuits
Online Access:	https://doi.org/10.15252/msb.20178102