Impact of germline panel size on hereditary cancer: findings of variants of uncertain significance in the Brazilian public health population selected for high hereditary cancer risk

IntroductionBreast cancer is the most common malignant neoplasm among women in Brazil, excluding non-melanoma skin cancers, with a significant proportion of hereditary cases associated with pathogenic or likely pathogenic germline variants (PV/LPV) in various genes. The increased use of multigene pa...

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Bibliographic Details

Published in:	Frontiers in Cancer Control and Society
Main Authors:	Christine Elisabete Rubio Alem, Bárbara Narciso Duarte, Ana Elisa Ribeiro da Silva Cabello, Sandra Regina Campos Teixeira, Thiago Gaspar, Márcio Lopes de Souza, Cesar Cabello
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	high risk germline mutations genetic testing breast cancer variants of uncertain significance (VUS)
Online Access:	https://www.frontiersin.org/articles/10.3389/fcacs.2025.1549584/full