PCNA Ubiquitylation: Instructive or Permissive to DNA Damage Tolerance Pathways?

DNA lesions escaping from repair often block the DNA replicative polymerases required for DNA replication and are handled during the S/G2 phases by the DNA damage tolerance (DDT) mechanisms, which include the error-prone translesion synthesis (TLS) and the error-free template switching (TS) pathways...

Full description

Bibliographic Details

Published in:	Biomolecules
Main Authors:	Jun Che, Xin Hong, Hai Rao
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Subjects:	DNA damage tolerance PCNA ubiquitylation TLS TS pathway choice
Online Access:	https://www.mdpi.com/2218-273X/11/10/1543