Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders

Abstract DNA sensing is a pivotal component of the innate immune system that is responsible for detecting mislocalized DNA and triggering downstream inflammatory pathways. Among the DNA sensors, cyclic GMP-AMP synthase (cGAS) is a primary player in detecting cytosolic DNA, including foreign DNA from...

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出版年:	Molecular Neurodegeneration
主要な著者:	Yige Huang, Bangyan Liu, Subhash C. Sinha, Sadaf Amin, Li Gan
フォーマット:	論文
言語:	英語
出版事項:	BMC 2023-11-01
主題:	cGAS STING Interferon response Cytosolic dsDNA Antiviral Neuroinflammation
オンライン･アクセス:	https://doi.org/10.1186/s13024-023-00672-x