Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders

Abstract DNA sensing is a pivotal component of the innate immune system that is responsible for detecting mislocalized DNA and triggering downstream inflammatory pathways. Among the DNA sensors, cyclic GMP-AMP synthase (cGAS) is a primary player in detecting cytosolic DNA, including foreign DNA from...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Molecular Neurodegeneration
المؤلفون الرئيسيون:	Yige Huang, Bangyan Liu, Subhash C. Sinha, Sadaf Amin, Li Gan
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	BMC 2023-11-01
الموضوعات:	cGAS STING Interferon response Cytosolic dsDNA Antiviral Neuroinflammation
الوصول للمادة أونلاين:	https://doi.org/10.1186/s13024-023-00672-x

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