Integrin αvβ5 Internalizes Zika Virus during Neural Stem Cells Infection and Provides a Promising Target for Antiviral Therapy

Summary: We perform a CRISPR-Cas9 genome-wide screen in glioblastoma stem cells and identify integrin αvβ5 as an internalization factor for Zika virus (ZIKV). Expression of αvβ5 is correlated with ZIKV susceptibility in various cells and tropism in developing human cerebral cortex. A blocking antibo...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Shaobo Wang, Qiong Zhang, Shashi Kant Tiwari, Gianluigi Lichinchi, Edwin H. Yau, Hui Hui, Wanyu Li, Frank Furnari, Tariq M. Rana
Format:	Article
Language:	English
Published:	Elsevier 2020-01-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124719314913