Evaluation of the Fill-it-up-design to use historical control data in randomized clinical trials with two arm parallel group design

Abstract Purpose In the context of clinical research, there is an increasing need for new study designs that help to incorporate already available data. With the help of historical controls, the existing information can be utilized to support the new study design, but of course, inclusion also carri...

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Bibliographic Details

Published in:	BMC Medical Research Methodology
Main Authors:	Stephanie Wied, Martin Posch, Ralf-Dieter Hilgers
Format:	Article
Language:	English
Published:	BMC 2024-09-01
Subjects:	Randomized clinical trial Historical control External controls Type I error probability Power Sample size
Online Access:	https://doi.org/10.1186/s12874-024-02306-2