Assessment of omeprazole and famotidine effects on the pharmacokinetics of tacrolimus in patients following kidney transplant–randomized controlled trial

Tacrolimus is metabolized in the liver with the participation of the CYP3A4 and CYP3A5 enzymes. Proton pump inhibitors are used in kidney transplant patients to prevent duodenal and gastric ulcer disease due to glucocorticoids. Omeprazole, unlike famotidine, is a substrate and inhibitor of the enzym...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Miłosz Miedziaszczyk, Marek Karczewski, Tomasz Grabowski, Anna Wolc, Ilona Idasiak-Piechocka
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-04-01
Subjects:	omeprazole famotidine tacrolimus pharmacokinetics kidney transplant pharmacotherapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1352323/full