Genotype-driven sensitivity of mice to tick-borne encephalitis virus correlates with differential host responses in peripheral macrophages and brain

Abstract Background Tick-borne encephalitis (TBE) is the most common tick-borne viral infection in Eurasia. Outcomes range from asymptomatic infection to fatal encephalitis, with host genetics likely playing a role. BALB/c mice have intermediate susceptibility to TBE virus (TBEV) and STS mice are hi...

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Bibliographic Details

Published in:	Journal of Neuroinflammation
Main Authors:	Michaela Berankova, Jiri Holoubek, Vaclav Hönig, Zuzana Matusova, Martin Palus, Jiri Salat, Imtissal Krayem, Jarmila Vojtiskova, Pavel Svoboda, Veronika Pranclova, Lukas Valihrach, Peter Demant, Marie Lipoldova, Daniel Ruzek
Format:	Article
Language:	English
Published:	BMC 2025-01-01
Subjects:	Tick-borne encephalitis Tick-borne encephalitis virus Mouse model Neuroinflammation Genetics Transcriptomics
Online Access:	https://doi.org/10.1186/s12974-025-03354-1