Identification of novel immuno-oncology compounds as VISTA-inhibitors for cancer therapy: A computational approach integrating virtual screening and molecular dynamics simulation

The landscape of cancer treatment has witnessed a paradigm shift with the emergence of immunotherapy, particularly the inhibition of immune checkpoints like programmed cell death protein 1 (PD-1) and its ligand PD-L1. While these therapies have revolutionized cancer treatment, a substantial proporti...

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Bibliographic Details

Published in:	Informatics in Medicine Unlocked
Main Authors:	Winner Amaka Egejuru, Olajide Enoch Aderemi, Abel Ujaigbe Egbemhenghe, Muhammad Qasim Ali, Dolapo Emmanuel Opasina, Cyril Obaro Agadagba, Emmanuel Parkay Oladokun, Ibrahim Tope Abdulrazaq, Maryam Folake Ayinla, Abiodun Bamidele, Olamide Oluwagbeminiyi Alayemi, Latifat Akorede Adebowale, Folakemi Monsurat Adebayo, Bamidele Samson Omotara
Format:	Article
Language:	English
Published:	Elsevier 2024-01-01
Subjects:	Virtual screening Molecular docking Molecular dynamics simulation VISTA Immune-oncology and cancer therapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352914824000170