Comparison of Transcriptomic Profiles of MiaPaCa-2 Pancreatic Cancer Cells Treated with Different Statins

Statins have been widely used for the treatment of hypercholesterolemia due to their ability to inhibit HMG-CoA reductase, the rate-limiting enzyme of de novo cholesterol synthesis, via the so-called mevalonate pathway. However, their inhibitory action also causes depletion of downstream intermediat...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Silvie Rimpelová, Michal Kolář, Hynek Strnad, Tomáš Ruml, Libor Vítek, Helena Gbelcová
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Subjects:	statins pancreatic cancer DNA microarray pitavastatin cerivastatin simvastatin
Online Access:	https://www.mdpi.com/1420-3049/26/12/3528