The role of neoantigens and tumor mutational burden in cancer immunotherapy: advances, mechanisms, and perspectives

Abstract Cancer immunotherapy has revolutionized oncology by leveraging the immune system to combat tumors. Among various biomarkers, neoantigens and tumor mutational burden (TMB) have emerged as critical factors in tailoring personalized treatments. Neoantigens are tumor-specific peptides displayed...

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Bibliographic Details

Published in:	Journal of Hematology & Oncology
Main Authors:	Shengbo Sun, Lanchun Liu, Jingkang Zhang, Liting Sun, Wenlong Shu, Zhengyang Yang, Hongwei Yao, Zhongtao Zhang
Format:	Article
Language:	English
Published:	BMC 2025-09-01
Subjects:	Tumor neoantigens Tumor mutational burden Immunotherapy Liquid biopsy Clinical trials
Online Access:	https://doi.org/10.1186/s13045-025-01732-z