Relative Quantitative Comparison between Lipotoxicity and Glucotoxicity Affecting the PARP-NAD-SIRT1 Pathway in Hepatocytes

Background/Aims: Insulin resistance in type 2 diabetes results from a combination of hyperglycemia and elevated free fatty acid (FFA) concentrations. However, the individual effects of glucotoxicity and lipotoxicity on cell function have not been determined. Methods: To compare the effects of increa...

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Bibliographic Details

Published in:	Cellular Physiology and Biochemistry
Main Authors:	Jing Pang, Chao Xi, Junhua Jin, Yiwen Han, Tie-mei Zhang
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2013-09-01
Subjects:	Cytotoxicity Free fatty acids Hyperglycemia Hepatocytes Poly (ADP)-ribose polymerase
Online Access:	http://www.karger.com/Article/FullText/354474