Frequency of synaptic antigen-specific CD4+ T cells in dementia is age-dependent but not correlated with cognitive impairment

Abstract Neurodegenerative dementias including Alzheimer disease severely impair cognitive and social abilities and are a major cause of mortality with no causal treatment yet. Autoimmune mechanisms have been increasingly considered to contribute to disease progression, e.g. by enhancing protein mis...

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Bibliographic Details

Published in:	Immunity & Ageing
Main Authors:	Julius Hoffmann, Marie-Luise Machule, Jakob Kreye, Laura Stöffler, Péter Körtvelyessy, Maria Buthut, Rosa Rößling, Petra Bacher, Alexander Scheffold, Harald Prüss
Format:	Article
Language:	English
Published:	BMC 2025-06-01
Subjects:	Synaptic autoantigens Immune senescence T cells Dementia NMDA receptor LGI1
Online Access:	https://doi.org/10.1186/s12979-025-00516-w