Anti-AAV Antibodies in AAV Gene Therapy: Current Challenges and Possible Solutions

Adeno-associated virus (AAV) vector-based gene therapy is currently the only in vivo gene therapy approved in the US and Europe. The recent tragic death of three children in a clinical trial to treat X-Linked Myotubular Myopathy by delivering myotubularin with an AAV8 vector notwithstanding, AAV rem...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Author:	Thomas Weber
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Subjects:	gene therapy aav antibodies antibody assays removal of antibodies removal of inhibitors
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.658399/full