Selective vulnerability of human-induced pluripotent stem cells to dihydroorotate dehydrogenase inhibition during mesenchymal stem/stromal cell purification

The use of induced mesenchymal stem/stromal cells (iMSCs) derived from human induced pluripotent stem cells (hiPSCs) in regenerative medicine involves the risk of teratoma formation due to hiPSCs contamination in iMSCs. Therefore, eradicating the remaining undifferentiated hiPSCs is crucial for the...

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書誌詳細

出版年:	Frontiers in Cell and Developmental Biology
主要な著者:	Ziadoon Al-Akashi, Denise Zujur, Daisuke Kamiya, Tomohisa Kato, Toru Kondo, Makoto Ikeya
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2023-02-01
主題:	mesenchymal stem/stromal cells (MSCs) induced mesenchymal stromal cells (iMSCs) induced pluripotent stem cells (hiPSC) pyrimidine biosynthesis dihydroorotate dehydrogenase (DHODH) brequinar (BRQ)
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fcell.2023.1089945/full