Translation of 5′ leaders is pervasive in genes resistant to eIF2 repression

Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions. This can be achieved by the phosphorylation-mediated inactivation of a key translation initiation factor, eukaryotic initiation factor 2 (eIF2). However, the persistent translation of certain mRNAs is require...

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Bibliographic Details

Published in:	eLife
Main Authors:	Dmitry E Andreev, Patrick BF O'Connor, Ciara Fahey, Elaine M Kenny, Ilya M Terenin, Sergey E Dmitriev, Paul Cormican, Derek W Morris, Ivan N Shatsky, Pavel V Baranov
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2015-01-01
Subjects:	upstream open reading frame eukaryotic initiation factor 2 integrated stress response ribosome profiling 5′ leader translation bicistronic mRNA
Online Access:	https://elifesciences.org/articles/03971