Pseudomonas aeruginosa lasR-deficient mutant contributes to bacterial virulence through enhancing the PhoB-mediated pathway in response to host environment

ABSTRACT Pseudomonas aeruginosa is a major opportunistic pathogen that causes lung infections in patients with cystic fibrosis and chronic obstructive pulmonary disease. Loss-of-function mutations in the quorum-sensing regulatory gene lasR commonly arise during chronic infections, which are associat...

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Bibliographic Details

Published in:	mBio
Main Authors:	Xiaolei Pan, Liwen Yin, Dandan Zhou, Yongxin Jin, Zhihui Cheng, Un-Hwan Ha, Shouguang Jin, Weihui Wu
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-10-01
Subjects:	Pseudomonas aeruginosa virulence quorum sensing LasR PhoB-PhoR
Online Access:	https://journals.asm.org/doi/10.1128/mbio.01788-25