Genomic landscape of locally advanced rectal adenocarcinoma: Comparison between before and after neoadjuvant chemoradiation and effects of genetic biomarkers on clinical outcomes and tumor response

Abstract Purpose To explore genomic biomarkers in rectal cancer by performing whole‐exome sequencing. Materials and Methods Pre‐chemoradiation (CRT) biopsy and post‐CRT surgical specimens were obtained from 27 patients undergoing neoadjuvant CRT followed by definitive resection. Exomes were sequence...

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Bibliographic Details
Published in:Cancer Medicine
Main Authors: Tae Hoon Lee, Bum‐Sup Jang, Ji Hyun Chang, Eunji Kim, Jeong Hwan Park, Eui Kyu Chie
Format: Article
Language:English
Published: Wiley 2023-07-01
Subjects:
neoadjuvant chemoradiation
rectal cancer
whole‐exome sequencing
Online Access:https://doi.org/10.1002/cam4.6169

Internet

https://doi.org/10.1002/cam4.6169

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