Towards Enhanced MRI Performance of Tumor-Specific Dimeric Phenylboronic Contrast Agents

It is known that phenylboronic acid (PBA) can target tumor tissues by binding to sialic acid, a substrate overexpressed by cancer cells. This capability has previously been explored in the design of targeting diagnostic probes such as Gd- and ⁶⁸Ga-DOTA-EN-PBA, two contrast age...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Jonathan Martinelli, Lorenzo Tei, Simonetta Geninatti Crich, Diego Alberti, Kristina Djanashvili
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Subjects:	gadolinium complexes MRI contrast enhancement phenylboronic acid sialic acid tumor targeting
Online Access:	https://www.mdpi.com/1420-3049/26/6/1730