Orphan receptor-GPR52 inverse agonist efficacy in ameliorating chronic stress-related deficits in reward motivation and phasic accumbal dopamine activity in mice

Abstract Reward processing dysfunctions e.g., anhedonia, apathy, are common in stress-related neuropsychiatric disorders including depression and schizophrenia, and there are currently no established therapies. One potential therapeutic approach is restoration of reward anticipation during appetitiv...

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Bibliographic Details

Published in:	Translational Psychiatry
Main Authors:	Chenfeng Zhang, Diana Kúkeľová, Hannes Sigrist, Bastian Hengerer, Ramona F. Kratzer, Philipp Mracek, Azar Omrani, Moritz von Heimendahl, Christopher R. Pryce
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-09-01
Online Access:	https://doi.org/10.1038/s41398-024-03081-w