Impact of Nitisinone on the Cerebrospinal Fluid Metabolome of a Murine Model of Alkaptonuria

Background: Nitisinone-induced hypertyrosinaemia is well documented in Alkaptonuria (AKU), and there is uncertainty over whether it may contribute to a decline in cognitive function and/or mood by altering neurotransmitter metabolism. The aim of this work was to evaluate the impact of nitisinone on...

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Bibliographic Details
Published in:Metabolites
Main Authors: Andrew S. Davison, Brendan P. Norman, Hazel Sutherland, Anna M. Milan, James A. Gallagher, Jonathan C. Jarvis, Lakshminarayan R. Ranganath
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Subjects:
Alkaptonuria
hypertyrosinaemia
neurotransmitters
cognitive function
Online Access:https://www.mdpi.com/2218-1989/12/6/477

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https://www.mdpi.com/2218-1989/12/6/477

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