MiR-181a-driven downregulation of cholesterol biosynthesis through SREBP2 inhibition suppresses uveal melanoma metastasis

Abstract Background uveal melanoma (UM) is the most common primary intraocular tumor in adults, with metastasis being the leading cause of death. However, effective treatments for metastatic UM remain limited. Emerging evidence suggests that cholesterol metabolism plays a role in cancer progression,...

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發表在:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Rui Wang, Claudia Gilbert, Houda Tahiri, Chun Yang, Solange Landreville, Pierre Hardy
格式:	Article
語言:	英语
出版:	BMC 2025-07-01
主題:	Uveal melanoma miR-181a Metastasis Cholesterol biosynthesis SREBP2 Crizotinib
在線閱讀:	https://doi.org/10.1186/s13046-025-03459-8