Computational Insights into Allosteric Conformational Modulation of P-Glycoprotein by Substrate and Inhibitor Binding

The ATP-binding cassette (ABC) transporter P-glycoprotein (P-gp) is a physiologically essential membrane protein that protects many tissues against xenobiotic molecules, but limits the access of chemotherapeutics into tumor cells, thus contributing to multidrug resistance. The atomic-level mechanism...

全面介紹

書目詳細資料

發表在:	Molecules
Main Authors:	Juan Xing, Shuheng Huang, Yu Heng, Hu Mei, Xianchao Pan
格式:	Article
語言:	英语
出版:	MDPI AG 2020-12-01
主題:	P-glycoprotein ABC transporter conformational changes molecular dynamics
在線閱讀:	https://www.mdpi.com/1420-3049/25/24/6006