Safety evaluations of a synthetic antimicrobial peptide administered intravenously in rats and dogs

Abstract The antimicrobial peptide SET-M33 is under study for the development of a new antibiotic against major Gram-negative pathogens. Here we report the toxicological evaluation of SET-M33 administered intravenously to rats and dogs. Dose range finding experiments determined the doses to use in t...

Full description

Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Laura Cresti, Chiara Falciani, Giovanni Cappello, Jlenia Brunetti, Silvia Vailati, Elsa Melloni, Luisa Bracci, Alessandro Pini
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-11-01
Online Access:	https://doi.org/10.1038/s41598-022-23841-2