hPDLSC-ApoEVs attenuate periodontitis and enhance bone regeneration via NF-κB/S100A9-Mediated M2 macrophage polarization

Abstract Background Periodontitis is the most prevalent oral disease worldwide, leading to inflammation, alveolar bone loss, and tooth loss. Mesenchymal stem cells (MSCs) transplantation has the potential to alleviate periodontitis and restore alveolar bone, but numerous studies have found that tran...

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Zeyu Zhang, Liting Zeng, Yang Yu, Zidan Xu, Guanxiong Zhu, Jinlong Weng, Junyi Xia, Weijie Peng, Qin Dong, Yuanyuan Li, Lingmin Zhang, Lu Liang, Janak Lal Pathak, Lina Yu
Format:	Article
Language:	English
Published:	BMC 2025-09-01
Subjects:	Periodontitis Extracellular vesicles Periodontal ligament stem cells Apoptosis Periodontal tissue regeneration
Online Access:	https://doi.org/10.1186/s13287-025-04617-7