Computational Insights into the Binding Mechanism of OxyS sRNA with Chaperone Protein Hfq

Under the oxidative stress condition, the small RNA (sRNA) OxyS that acts as essential post-transcriptional regulators of gene expression is produced and plays a regulatory function with the assistance of the RNA chaperone Hfq protein. Interestingly, experimental studies found that the N48A mutation...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Mengxin Li, Yalong Cong, Yifei Qi, John Z. H. Zhang
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Subjects:	small RNA OxyS RNA chaperone Hfq protein gene expression regulator molecular dynamics simulations binding free energy interaction entropy
Online Access:	https://www.mdpi.com/2218-273X/11/11/1653