Characterization of an unusual SARS-CoV-2 main protease natural variant exhibiting resistance to nirmatrelvir and ensitrelvir

Abstract We investigate the effects of two naturally selected substitution and deletion (Δ) mutations, constituting part of the substrate binding subsites S2 and S4, on the structure, function, and inhibition of SARS CoV-2 main protease. Comparable to wild-type, MProD48Y/ΔP168 undergoes N-terminal a...

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Bibliographic Details

Published in:	Communications Biology
Main Authors:	Dipendra Bhandari, Oksana Gerlits, Stephen Keable, Leighton Coates, Annie Aniana, Rodolfo Ghirlando, Nashaat T. Nashed, Andrey Kovalevsky, John M. Louis
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Online Access:	https://doi.org/10.1038/s42003-025-08487-w