Chemonucleolysis combined with dynamic loading for inducing degeneration in bovine caudal intervertebral discs

Chemonucleolysis has become an established method of producing whole organ culture models of intervertebral disc (IVD) degeneration. However, the field needs more side-by-side comparisons of the degenerative effects of the major enzymes used in chemonucleolysis towards gaining a greater understandin...

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Bibliographic Details

Published in:	Frontiers in Bioengineering and Biotechnology
Main Authors:	Andrea Vernengo, Helen Bumann, Nadine Kluser, Astrid Soubrier, Amra Šećerović, Jan Gewiess, Jan Ulrich Jansen, Cornelia Neidlinger-Wilke, Hans-Joachim Wilke, Sibylle Grad
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-08-01
Subjects:	organ culture chemonucleolysis (CN) intervertebral disc degeneration extracellular matrix
Online Access:	https://www.frontiersin.org/articles/10.3389/fbioe.2023.1178938/full