Double and single stranded detection of 5-methylcytosine and 5-hydroxymethylcytosine with nanopore sequencing
Abstract 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are modified versions of cytosine in DNA with roles in regulating gene expression. Using whole genomic DNA from mouse cerebellum, we benchmark 5mC and 5hmC detection by Oxford Nanopore Technologies sequencing against other standard t...
| Published in: | Communications Biology |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s42003-025-07681-0 |