Hypoxia potentiates the capacity of melanoma cells to evade cisplatin and doxorubicin cytotoxicity via glycolytic shift

The hypoxic environment within solid tumors impedes the efficacy of chemotherapeutic treatments. Here, we demonstrate that hypoxia augments the capacity of melanoma cells to withstand cisplatin and doxorubicin cytotoxicity. We show that B16F10 cells derived from spontaneously formed melanoma and YUM...

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Bibliographic Details

Published in:	FEBS Open Bio
Main Authors:	Ming Zhuo, Falih M. Gorgun, Douglas S. Tyler, Ella W. Englander
Format:	Article
Language:	English
Published:	Wiley 2020-05-01
Subjects:	cisplatin doxorubicin glycolysis hypoxia melanoma mitochondrial respiration
Online Access:	https://doi.org/10.1002/2211-5463.12830